Advanced Technology, Efficacious Outcomes

Cynergy treats vascular and pigmented lesions more effectively than conventional, single-wavelength platforms. With both a high-powered 585 nm pulsed-dye laser and a 1064 nm Nd:YAG laser, our proprietary MultiPlex technology enables the sequential emission of two wavelengths from one delivery system for optimized clinical effectiveness.

The Science of MultiPlexTM

Sequential emission means that Cynergy’s sub-purpuric, pulsed-dye laser fires milliseconds before the Nd:YAG laser. This first pulse converts oxy-hemoglobin to methemoglobin, which increases the absorption coefficient for the Nd:YAG wavelength by 300–500%.2,3

Next, the Nd:YAG laser fires and is more effectively absorbed by the converted target, enabling reduced Nd:YAG fluence for enhanced patient safety. Since greater penetration depth is achieved, outcome results are also optimized.

By emitting dual wavelengths, Cynergy provides safe and effective results in less time than single-wavelength systems. For your patients, that means greater comfort and satisfaction. For you, that means greater patient throughput.

1Geronemus R J Dermatol Surg Oncol. 1993;19:303–310.

2Barton JK, et al. Optical and magnetic resonance changes in photothermally coagulating blood. Proceedings of SPIE 2002; 4609:10-19.

3Kuenstner JT, Norris KH. Spectrophotometry of human hemoglobin in the near infrared region from 1000 to 2500 nm. Near Infrared Spectrosc 1994;2:59-65.



Cynergy Vascular Workstation Specifications


Before & After


I use the [Cynergy Vascular Workstation] in my practice every day. It has quickly become my ‘workhorse’ system for a variety of dermatologic conditions, including facial and leg telangiectasias, port-wine stains, hemangiomas, and hypertrophic scars. I have been so impressed with the versatility of the Cynergy system that I have discontinued the use of a couple of my single-wavelength laser systems.

Events & Media

Clinical Data

As a recognized industry leader, our technology—including Cynergy technology—is strongly supported by clinical research.

  1. Alster TS, Tanzi EL. Combined 595-nm and 1,064-nm laser irradiation of recalcitrant and hypertrophic port-wine stains in children and adults. Dermatol Surg 2009;35(6):914-8; discussion 918-9. doi: 10.1111/j.1524-4725.2009.01155.x. Epub 2009 Apr 9.
  2. Boixeda, P., et al. Advances in treatment of cutaneous and subcutaneous vascular anomalies by pulsed dual wavelength 595- and 1064-nm application. Medical Laser Application 2008;23:121–126.
  3. González, J.A., et al. Angiolymphoid hyperplasia with eosinophilia treated with vascular laser. Lasers Med Sci 2011;26(3):285-90. doi: 10.1007/s10103-011-0892-3. Epub 2011 Feb 24.
  4. Jung, J.Y.,et al. Comparison of a pulsed dye laser and a combined 585/1,064-nm laser in the treatment of acne vulgaris. Dermatol Surg 2009;35(8):1181-7. doi: 10.1111/j.1524-4725.2008.34427.x. Epub 2009 Jan 21.
  5. Karsai, S., Roos, S., Raulin, C. Treatment of facial telangiectasia using a dual-wavelength laser system (595 and 1,064 nm): a randomized controlled trial with blinded response evaluation. Dermatol Surg 2008;34(5):702-8. doi: 10.1111/j.1524-4725.2008.34131.x. Epub 2008 Mar 3.
  6. Larson, A.A., Goldman, M.P. Recalcitrant rosacea successfully treated with multiplexed pulsed dye laser. J Drugs Dermatol 2007;6(8):843-5.
  7. Li, G., Sun, J., Shao, X., Sang, H., Zhou, Z. The effects of 595- and 1,064-nm lasers on rooster comb blood vessels using dual-wavelength and multipulse techniques. Dermatol Surg 2011;37(10):1473-9. doi: 10.1111/j.1524-4725.2011.02090.x. Epub 2011 Jul 18.
  8. Min, S., et al. Comparison of a long-pulse Nd:YAG laser and a combined 585/1,064-nm laser for the treatment of acne scars: a randomized split-face clinical study. Dermatol Surg 2009;35(11):1720-7. doi: 10.1111/j.1524-4725.2009.01086.x. Epub 2009 Feb 22.
  9. Mordon S, Brisot D, Fournier N. Using a “Non Uniform Pulse Sequence” can improve selective coagulation with a Nd:YAG laser (1.06 microm) thanks to Met-hemoglobin absorption: a clinical study on blue leg veins. Lasers Surg Med 2003;32(2):160-70.
  10. Saafan AM, Salah MM. Using pulsed dual-wavelength 595 and 1064 nm is more effective in the management of hemangiomas. J Drugs Dermatol 2010;9(4):310-4.
  11. Saluja, R. Laser Treatment for Venous Lakes. Review of Ophthalmology. Jobson Medical Information LLC 2011.
  12. Saluja, R. Laser Treatment Aids Rosacea Patients. In: Bernardino, R.C. ed. Review of Opthomology. Aug 2009.
  13. Tanghetti E, Sherr E. Treatment of telangiectasia using the multi-pass technique with the extended pulse width, pulsed dye laser (Cynosure V-Star). J Cosmet Laser Ther 2003;5(2):71-5.
  14. Trelles MA, Weiss R, Moreno-Moragas J, Romero C, Vélez M, Alvarez X. Treatment of leg veins with combined pulsed dye and Nd:YAG lasers: 60 patients assessed at 6 months. Lasers Surg Med 2010;42(9):609-14. doi: 10.1002/lsm.20972.
  15. Tenenbaum, M.J. Cynergy vascular workstation treats rosacea and facila redness with excellent results . Cynosure Whitepaper . 921-0130-000.
  16. Alster, T.S. Cynergy Multiplex Treatment of Port-Wine Stains. Cynosure Whitepaper 2007. 921-5000-000.
  17. Enokibori, M. Treatment of Photoaging in Asian Skin Using Cynergy Pulse Dye (PDL)/Nd:YAG with MultiPlex Feature. Cynosure Whitepaper 2007. 921-1012-000.
  18. Enokibori, M. Pilot Treatment of Vascular Lesions in Asian Skin Types with the Cynergy Pulse Dye (PDL)/Nd:YAG MultiPlex Laser. Cynosure Whitepaper 2007. 921-1011-000.
  19. Neugebauer, D. Treatment of Psoriasis using the 0.45-msec, 585-nm Pulse Dye Laser (PhotoGenica V). Cynosure Whitepaper 2001.
  20. Tanghetti, E. Cynergy with MultiPlex™ Treatment of Telangiectasia. Cynosure Whitepaper 2006. 920-0294-000
  21. Taylor, M.B. MultiPlex 1064/585 nm Laser Treatment of Vascular Lesions. Cynosure Whitepaper 2007. 921-1014-000
  22. Adatto, M. Facial Veins. Cynergy Case Report. 921-0018-000.
  23. Adatto, M. Leg Veins. Cynergy Case Report. 921-0019-000.
  24. Adrian, R. MultiPlex for Leg Veins: Treatment Techniques and Observations. Cynergy Case Report. 921-0387-000
  25. Goldman, M.P., Keel, D.M. Facial Telangiectasia and Facial Rejuvenation. Cynergy Case Report 921-0377-000.
  26. Tanghetti, E. Cynergy with MultiPlex™ Treatment of Telangiectasia. Cynergy Case Report 921-0294-000.
  27. Barton JK, et al. Optical and magnetic resonance changes in photothermally coagulating blood. Proceedings of SPIE 2002; 4609:10-19.
  28. Kuenstner JT, Norris KH. Spectrophotometry of human hemoglobin in the near infrared region from 1000 to 2500 nm. Near Infrared Spectrosc 1994;2:59-65.